Bio Informatics

BM6005
CSE IT

Unit 1

INTRODUCTION

Need for Bioinformatics technologies – Overview of Bioinformatics technologies Structural bioinformatics – Data format and processing – Secondary resources and applications – Role of Structural bioinformatics - Biological Data Integration System. 97

Part A (2m) Part B (16m)

Unit 2

DATAWAREHOUSING AND DATAMINING IN BIOINFORMATICS

Bioinformatics data – Data warehousing architecture – data quality – Biomedical data analysis – DNA data analysis – Protein data analysis – Machine learning – Neural network architecture and applications in bioinformatics. I

Part A (2m) Part B (16m)

Unit 3

MODELING FOR BIOINFORMATICS

Hidden markov modeling for biological data analysis – Sequence identification –Sequence classification – multiple alignment generation – Comparative modeling –Protein modeling – genomic modeling – Probabilistic modeling – Bayesian networks – Boolean networks - Molecular modeling – Computer programs for molecular modeling.

Part A (2m) Part B (16m)

Unit 4

PATTERN MATCHING AND VISUALIZATION

Gene regulation – motif recognition – motif detection – strategies for motif detection – Visualization – Fractal analysis – DNA walk models – one dimension – two dimension – higher dimension – Game representation of Biological sequences – DNA, Protein, Amino acid sequences.

Part A (2m) Part B (16m)

Unit 5

MICROARRAY ANALYSIS

Microarray technology for genome expression study – image analysis for data extraction – preprocessing – segmentation – gridding – spot extraction – normalization, filtering – cluster analysis – gene network analysis – Compared Evaluation of Scientific Data Management Systems – Cost Matrix – Evaluation model - Benchmark – Tradeoffs.

Part A (2m) Part B (16m)
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